‘Intersecting Pandemics’ project is an ongoing project here at CAAN. We know that Pandemic experiences are not new to Indigenous Peoples of North America; introducing and spreading infectious disease was a strategy of colonizing nations to claim lands and resources without resistance. CAAN are leaders in responding to HIV and AIDS in Indigenous communities in Canada with a mandate to lead and support research relevant to Indigenous organizations and communities impacted by HIV, Hepatitis C (HCV), tuberculosis (TB) and other co-infections. We witness Indigenous Peoples navigating ongoing and layered syndemics every day. For this reason, CAAN’s research mandate is strengths-based, culturally safe, and grounded in Indigenous knowledges and solutions. CAAN’s research with Indigenous-led front-line service organizations responding to HIV, HCV, and TB lays a foundation to sustain a response to the continually evolving COVID-19 situation and its consequences for intersecting pandemics. This research is working to support identifying, implementing, and sharing culturally safe, Indigenous community-led solutions to address the COVID-19 pandemic and its consequences by addressing the research areas of culturally safe covid-19 prevention, preparedness, response (and recovery) for Indigenous peoples. Our research is supported by Indigenous-led front-line organizations in Halifax, Toronto, Thunder Bay, Regina, and Red Deer. Given the national scope of this project and direct engagement with front-line service organizations we believe the learnings from this project will generate valuable insight into pandemic prevention, preparedness and response. This work will also provide an opportunity to engage Indigenous youth in mobilizing this knowledge through future research, and through CAAN’s next iteration of our Youth Council.